Antioxidant properties of 1,2,3,4,6-penta-O-galloyl-beta-D-glucose from Elaeocarpus sylvestris var. ellipticus

作者：Piao Mei Jing; Kang Kyoung Ah; Zhang Rui; Ko Dong Ok; Wang Zhi Hong; Lee Keun Hwa; Chang Weon Young; Chae Sungwook; Jee Youngheun; Shin Taekyun; Park Jae Woo; Lee Nam Ho; Hyun Jin Won^*

来源：Food Chemistry, 2009, 115(2): 412-418.

DOI：10.1016/j.foodchem.2008.12.020

• Elaeocarpus sylvestris var. ellipticus
• Antioxidant
• 1,2,3,4,6-Penta-O-galloyl-beta-D-glucose (PGG)
• Antioxidant enzyme

The antioxidant potential of 1,2,3,4,6-penta-O-galloyl-beta-D-glucose (PGG), isolated from Elaeocarpus sylvestris var. ellipticus, was investigated by various established systems based on cell-free and cell system experiments, such as radical detection, antioxidant enzyme assay, lipid peroxidation detection, and cell viability assay. PGG was found to quench the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical and intracellular reactive oxygen species. PGG recovered the cellular antioxidant enzyme activities of superoxide dismutase, catalase, and glutathione peroxidase, which were reduced by H(2)O(2) treatment, thereby resulting in the inhibition of lipid peroxidation. Cytoprotective effects of PGG were based on the results of DNA fragmentation, mitochondrial membrane potential (Delta psi), apoptotic body formation, and caspase-3 activity. The results suggest that PGG protects cells against H(2)O(2)-induced cell damage via antioxidant properties.

• 出版日期2009-7-15