Alcohol use and non-adherence to antiretroviral therapy in HIV-infected patients in West Africa

作者：Jaquet Antoine^*; Ekouevi Didier K; Bashi Jules; Aboubakrine Maiga; Messou Eugene; Maiga Moussa; Traore Hamar Alassane; Zannou Marcel Djimon; Guehi Calixte; Ba Gomis Franck Olivier; Minga Albert; Allou Gerard; Eholie Serge Paul; Bissagnene Emmanuel; Sasco Annie J; Dabis Francois

来源：Addiction, 2010, 105(8): 1416-1421.

DOI：10.1111/j.1360-0443.2010.02978.x

• Adherence
• alcohol use
• antiretroviral treatment
• HIV
• AIDS
• subSaharan Africa

Aim
To investigate the association between alcohol use and adherence to highly active antiretroviral treatment (HAART) among human immunodeficiency virus (HIV)-infected patients in subSaharan Africa.
Design and setting
Cross-sectional survey conducted in eight adult HIV treatment centres from Benin, Cote d'Ivoire and Mali.
Participants and measurements
During a 4-week period, health workers administered the Alcohol Use Disorders Identification Test to HAART-treated patients and assessed treatment adherence using the AIDS Clinical Trials Group follow-up questionnaire.
Findings
A total of 2920 patients were enrolled with a median age of 38 years [interquartile range (IQR) 32-45 years] and a median duration on HAART of 3 years (IQR 1-4 years). Overall, 91.8% of patients were identified as adherent to HAART. Non-adherence was associated with current drinking [odds ratio (OR) 1.4; 95% confidence interval (CI) 1.1-2.0], hazardous drinking (OR 4.7; 95% CI 2.6-8.6) and was associated inversely with a history of counselling on adherence (OR 0.7; 95% CI 0.5-0.9).
Conclusions
Alcohol consumption and hazardous drinking is associated with non-adherence to HAART among HIV-infected patients from West Africa. Adult HIV care programmes should integrate programmes to reduce hazardous and harmful drinking.

• 出版日期2010-8