Axially chiral BODIPYs

作者：Lerrick Reinner I; Winstanley Thomas P L; Haggerty Karen; Wills Corinne; Clegg William; Harrington Ross W; Bultinck Patrick; Herrebout Wouter; Benniston Andrew C; Hall Michael J^*

来源：Chemical Communications, 2014, 50(36): 4714-4716.

DOI：10.1039/c4cc00851k

The synthesis and resolution of a class of chiral organic fluorophores, axially chiral 4,4-difluoro-4-bora-3a,4a-diaza-s-indacenes (Ax*-BODIPY), is described. Ax*-BODIPYs were prepared through a modular synthesis combined with a late stage Heck functionalisation. Resolution was achieved by preparative chiral HPLC. Absolute stereochemical assignment was performed by comparison of experimental ECD spectra with TD-DFT calculations.

• 出版日期2014