An artificial photosensitizer drug network for mitochondria-selective photodynamic therapy

作者:Park So Young; Oh Kyung Taek; Oh Young Taik; Nam Muk Oh; Youn Yu Seok; Lee Eun Seong*
来源:Chemical communications, 2012, 48(19): 2522-2524.
DOI:10.1039/c2cc16087k

摘要

We report a new class of photosensitizer drug networks that can home into mitochondria and provide geospatial phototoxicity for tumors. We take advantage of the cleavable chemical network between the photosensitizer drug and poly(ethylene glycol), and find a significant increase in the efficiency of the multimeric drug network in mitochondria uptake and tumor inhibition.

  • 出版日期2012