Apoptosis of human highly metastatic lung cancer cell line 95-D induced by acutiaporberine, a novel bisalkaloid derived from Thalictrum acutifolium

作者：Chen, Q; Peng, WL; Qi, SJ; Xu, AL^*

来源：Planta Medica, 2002, 68(6): 550-553.

DOI：10.1055/s-2002-32546

The present study demonstrates for the first time that acutiaporberine, a bisalkaloid isolated from the tranditional Chinese medical herb Thalictrum acutifolium (Hand.-Mazz.) Boivin. (TAB), induces apoptosis of a cultured highly metastatic human lung cancer cell line 95-D. Immunohistochemistry assay (1HC) and Western-blot analysis show down-regulation of bcl-2 gene and upregulation of bax gene and c-myc gene in the treated cells. These results suggest that acutiaporberine may be a natural potential apoptosis-inducing agent for highly metastatic lung cancer.

• 出版日期2002-6
• 单位中山大学