Unique cation binding capability of cyclic oligo(L-lactic acid) (L-COLA)

作者：Kogame Chizuru; Kida Toshiyuki; Fujiwara Tomoko; Akashi Mitsuru^*

来源：Tetrahedron Letters, 2015, 56(13): 1675-1678.

DOI：10.1016/j.tetlet.2015.02.037

• Cyclic lactic acid
• Oligomer
• Macrocyclization
• Cation binding
• Size selectivity

Cyclic L-lactic acid octamer (L-COLA-8) shows a unique complexing capability towards alkali and alkali earth metal cations in acetonitrile-d(3)/chloroform-d (9/1). The valence of the cation affects the stoichiometry of the complexes between L-COLA-8 and the cation; L-COLA-8 forms a 2:1 complex with alkali metal cations, but forms a 1:1 complex with alkali earth metal cations. Additionally, L-COLA-8 shows a binding selectivity for Rb* and Ba2+, which have a diameter about 3 angstrom.

• 出版日期2015-3-25