Antibiotic susceptibility and molecular epidemiology of Panton-Valentine leukocidin-positive meticillin-resistant Staphylococcus aureus: An international survey

作者：Macedo-Vinas, Marina^*; Conly, John; Francois, Patrice; Aschbacher, Richard; Blanc, Dominique S.; Coombs, Geoffrey; Daikos, George; Dhawan, Benu; Empel, Joanna; Etienne, Jerome; Sa Figueiredo, Agnes Marie; Golding, George; Han, Lizhong; Kim, Hong Bin; Koeck, Robin; Larsen, Anders; Layer, Franziska; Lo, Janice; Maeda, Tadashi; Mulvey, Michael; Pantosti, Annalisa; Saga, Tomoo; Schrenzel, Jacques; Simor, Andrew; Skov, Robert; Van Rijen, Miranda; Wang, Hui; Zakaria, Zunita

来源：Journal of Global Antimicrobial Resistance, 2014, 2(1): 43-47.

DOI：10.1016/j.jgar.2013.08.003

• Meticillin-resistant Staphylococcus aureus
• Panton-Valentine leukocidin
• Antibiotic multiresistance
• Molecular epidemiology

The antibiotic susceptibility and molecular epidemiology of Panton-Valentine leukocidin (PVL)-positive meticillin-resistant Staphylococcus aureus (MRSA) isolates reported from 17 countries in the Americas,. Europe and, Australia-Asia were analysed. Among a total of 3236 non-duplicate isolates, the lowest susceptibility was observed to erythromycin in all regions. Susceptibility to ciprofloxacin showed large variation (25%, 75% and 84% in the Americas, Europe and Australia-Asia, respectively). Two vancomycinintermediate PVL-positive MRSA isolates were reported, one from Hong Kong and the other from The Netherlands. Resistance to trimethoprim/sulfamethoxazole and linezolid was <1%. Among 1798 MRSA isolates from 13 countries that were tested for the requested 10 non-beta-lactam antibiotics, 49.4% were multisusceptible. However, multiresistant isolates (resistant to at least three classes of non-beta-lactam antibiotics) were reported from all regions. Sequence type 30 (ST30) was reported worldwide, whereas ST80 and ST93 were exclusive to Europe and Australia, respectively. USA300 and related clones (ST8) are progressively replacing the ST80 clone in several European countries. Eight major clusters were discriminated by multilocus variable-number tandem repeat assay (MLVA), showing a certain geographic specificity. PVL-positive MRSA isolates frequently remain multisusceptible to non-beta-lactam agents, but multiresistance is already prevalent in all regions. Surveillance of MRSA susceptibility patterns should be monitored to provide clinicians with the most current information regarding changes in resistance patterns.

• 出版日期2014-3
• 单位中国医学科学院北京协和医院; 河北医科大学; 上海市闵行区中心医院