Association of polymorphisms in the AGT gene with essential hypertension in the Chinese population

作者：Xi, Bo; Shen, Yue; Yan, Yinkun; Mi, Jie^*

来源：Journal of the Renin-Angiotensin-Aldosterone System, 2012, 13(2): 282-288.

DOI：10.1177/1470320311430991

• AGT
• Chinese
• hypertension
• meta-analysis
• polymorphism

Objective: Although the angiotensinogen (AGT) gene has been implicated in the pathogenesis of essential hypertension, the results have been inconsistent. In this study, we performed a meta-analysis to assess the association of A-6G, A-20C and G-217A polymorphisms in the AGT gene with essential hypertension in the Chinese population. @@@ Methods: Published literature from PubMed, Embase, China National Knowledge Infrastructure, China Biological Medicine and Wanfang Data was retrieved. Pooled odds ratio (OR) with 95% confidence interval (CI) was calculated using fixed- or random-effects models. @@@ Results: Sixteen studies (4223 cases and 3743 controls) for A-6G polymorphism, ten studies (3116 cases and 2678 controls) for A-20C polymorphism and five studies (1268 cases and 1081 controls) for G-217A polymorphism were identified. The results from the meta-analyses indicated significant association of all three polymorphism with the risk of essential hypertension in the Chinese population (A-6G polymorphism: GG vs AA: OR = 1.45, 95% CI 1.17-1.81; A-20C polymorphism: CC vs AA: OR = 1.52, 95% CI 1.10-2.08; G-217A polymorphism: AA vs GG: OR = 2.36, 95% CI 1.44-3.89). @@@ Conclusions: Our study indicated that three polymorphisms (A-6G, A-20C and G-217A) in the AGT gene are associated with essential hypertension in the Chinese population.

• 出版日期2012-6
• 单位山东大学; 首都儿科研究所