A Liposomal Delivery Vehicle for the Anticancer Agent Gossypol

作者:Zhai Guangxi; Wu Jun; Zhao Xiaobin; Yu Bo; Li Hong; Lu Yanhui; Ye Weiping; Lin Young C; Lee Robert J*
来源:Anticancer Research, 2008, 28(5A): 2801-2805.

摘要

Background: Gossypol has recently been identified as a potential anticancer agent. In this study, a novel liposomal formulation is evaluated for delivery of gossypol. Materials and Methods: Gossypol was incorporated into liposomes. The liposomes were characterized for physical and chemical properties and for in vitro cytotoxicity. Results: Gossypol was stably encapsulated in these liposomes and exhibited cytotoxicity towards cancer cells. Conclusion: Liposomes can be used effectively as gossypol carriers.