Differences among Pollen-Allergic Patients with and without Plant Food Allergy

作者：Cuesta Herranz Javier^*; Barber Domingo; Blanco Carlos; Cistero Bahima Ana; Crespo Jesus F; Fernandez Rivas Montserrat; Fernandez Sanchez Javier; Fernando Florido J; Dolores Ibanez M; Rodriguez Rosalia; Salcedo Gabriel; Garcia Blanca E; Lombardero Manuel; Quiralte Joaquin; Rodriguez Julia; Sanchez Monge Rosa; Vereda Andrea; Villalba Mayte; Alonso Diaz de Durana M Dolores; Basagana Maria; Carrillo Teresa; Fernandez Nieto Mar; Tabar Ana I

来源：International Archives of Allergy and Immunology, 2010, 153(2): 182-192.

DOI：10.1159/000312636

• Pollen allergy
• Plant food allergy
• Component-resolved diagnostics
• Pru p 3
• Profilin
• Asthma
• Immunotherapy

Background: A considerable number of pollen-allergic patients develops allergy to plant foods, which has been attributed to cross-reactivity between food and pollen allergens. The aim of this study was to analyze the differences among pollen-allergic patients with and without plant food allergy. Methods: Eight hundred and six patients were recruited from 8 different hospitals. Each clinical research group included 100 patients (50 plant food-allergic patients and 50 pollen-allergic patients). Diagnosis of pollen allergy was based on typical case history of pollen allergy and positive skin prick tests. Diagnosis of plant-food allergy was based on clear history of plant-food allergy, skin prick tests and/or plant-food challenge tests. A panel of 28 purified allergens from pollens and/or plant foods was used to quantify specific IgE (ADVIA-Centaur (R) platform). Results: Six hundred and sixty eight patients (83%) of the 806 evaluated had pollen allergy: 396 patients with pollen allergy alone and 272 patients with associated food and pollen allergies. A comparison of both groups showed a statistically significant increase in the food and pollen allergy subgroup in frequency of: (1) asthma (47 vs. 59%; p < 0.001); (2) positive skin test results to several pollens: Plantago, Platanus, Artemisia, Betula, Parietaria and Salsola (p < 0.001); (3) sensitization to purified allergens: Pru p 3, profilin, Pla a 1 - Pla a 2, Sal k 1, PR-10 proteins and Len c 1. Conclusion: Results showed relevant and significant differences between both groups of pollen-allergic patients depending on whether or not they suffered from plant-derived food allergy.

• 出版日期2010