Antifungal Agents Spectrum of Activity, Pharmacology, and Clinical Indications

作者：Nett Jeniel E; Andes David R^*

来源：Infectious Disease Clinics of North America, 2016, 30(1): 51-+.

DOI：10.1016/j.idc.2015.10.012

• Antifungal
• Spectrum of activity
• Azole
• Echinocandins
• Amphotericin B
• Pharmacokinetics
• Indications
• Toxicity

The currently available antifungal therapies vary significantly in terms of spectrum of activity, pharmacologic properties, toxicity, and potential for drug-drug interactions. This article provides a history of antifungal development and discusses the characteristics of individual drugs and drug classes, including the amphotericin B formulations, the triazoles, the echinocandins, and flucytosine. For each drug, the clinically relevant pharmacokinetics are reviewed, the spectrum of activity described, and the Food and Drug Administration-approved clinical indications examined. Anti fungal side-effects, therapeutic drug monitoring, and drug-drug interactions are summarized. The variations among different formulations are highlighted.

• 出版日期2016-3