A chiral sensor for recognition of DOPA enantiomers based on immobilization of beta-cyclodextrin onto the carbon nanotube-ionic liquid nanocomposite

作者：Chen Ya; Huang Yihan; Guo Dongmei; Chen Cui; Wang Qinghong; Fu Yingzi^*

来源：Journal of Solid State Electrochemistry, 2014, 18(12): 3463-3469.

DOI：10.1007/s10008-014-2575-z

• Chiral discrimination
• DOPA enantiomers
• Ionic liquid
• Carbon nanotubes
• beta-cyclodextrin

A sensitive electrochemical method was explored for chiral recognition of 3,4-dihydroxyphenylalanine (DOPA) enantiomers based on immobilization of beta-cyclodextrin (beta-CD) onto the nanocomposite comprising multiwalled carbon nanotubes (MWCNTs) and ionic liquid (IL) 1-butyl-3-methylimidazolium hexafluorophosphate (BIMIMPF6) modified glassy carbon electrode (beta-CD/MWCNTs-IL/GCE). The combination of ionic liquid and carbon nanotubes could create unique nanomaterials which facilitated the electron transfer. In addition, beta-CD was brought in to act as the chiral selector for DOPA enantiomers recognition. The immobilization process of beta-CD/MWCNTs-IL/GCE was monitored by cyclic voltammetry, electrochemical impedance spectroscopy, and scanning electron microscopy. The chiral interface (beta-CD/MWCNTs-IL/GCE) was employed to discriminate DOPA enantiomers via differential pulse voltammetry. The results indicated that the proposed sensor exhibited a stronger electrochemical response toward D-DOPA over the linear range from 4.0 x 10(-3) to 4.0 x 10(-9) mol L-1 and the detection limit was 1.2 x 10(-9) mol L-1 (S/N = 3). This work provided an available platform for enantioselective recognition of DOPA enantiomers based on the nanocomposite.

• 出版日期2014-12
• 单位西南大学