Neoadjuvant chemotherapy as ovarian cancer treatment: ever more used with major regional differences

作者：Fago Olsen Carsten L^*; Ottesen Bent; Kehlet Henrik; Markauskas Algirdas; Mosgaard Berit J; Ottosen Christian; Sogaard Charlotte H; Sogaard Andersen Erik; Hogdall Claus

来源：Danish Medical Journal, 2012, 59(8): A4477.

INTRODUCTION: The traditional first-line treatment for patients with advanced ovarian cancer with primary debulking surgery (PDS) and adjuvant chemotherapy is controversial as some authors report a potential benefit from the alternative treatment with neoadjuvant chemotherapy (NACT) and interval debulking surgery. The aim of this study was to investigate the use of NACT in Denmark in regard to increased use and regional differences. %26lt;br%26gt;MATERIAL AND METHODS: Stage IIIC and IV ovarian cancer patients treated in the five Danish tertiary referral centres in the 2005-2010-period were included. The study is based on validated data from The Danish Gynaecological Cancer Database. %26lt;br%26gt;RESULTS: Of the 1,367 eligible patients 1,069 were treated with PDS and 298 with NACT. In 2005-2007, 11% of patients were treated with NACT. In 2008-2010, this percentage had risen to 30% (p %26lt; 0.00001). Between the five referral centres, the use of NACT ranged from 6% to 41% in 2005-2010 (p %26lt; 0.00001); from 1% to 31% in 2005-2007 (p %26lt; 0.00001); from 10% to 48% in 2008-2010 (p %26lt; 0.00001) and from 9% to 48% in 2010 (p %26lt; 0.0008). Patients treated with NACT were significantly older, had inferior ASA scores and Eastern Cooperative Oncology Group performance status compared with the patients from the PDS group. There was no difference between treatments in regard to body mass index, stage IV disease or patients with no co-morbidity. %26lt;br%26gt;CONCLUSION: The use of NACT as first-line treatment tripled from 2005-2010, but the regional variability was large which calls for a uniform agreement on treatment principles and evaluation.

• 出版日期2012-8