A role for the membrane Golgi protein Ema in autophagy

作者：Kim Sungsu; DiAntonio Aaron^*

来源：Autophagy, 2012, 8(8): 1269-1270.

DOI：10.4161/auto.20871

• Ema
• Clec16A
• Golgi
• autophagy
• Drosophila
• fat body
• growth

Autophagy is a cellular homeostatic response that involves degradation of self-components by the double-membraned autophagosome. The biogenesis of autophagosomes has been well described, but the ensuing processes after autophagosome formation are not clear. In our recent study, we proposed a model in which the Golgi complex contributes to the growth of autophagic structures, and that the Drosophila melanogaster membrane protein Ema promotes this process. In fat body cells of the D. melanogaster ema mutant, the recruitment of the Golgi complex protein Lava lamp (Lva) to autophagic structures is impaired and autophagic structures are very small. In addition, in the ema mutant autophagic turnover of SQSTM1/p62 and mitophagy are impaired. Our study not only identifies a role for Ema in autophagy, but also supports the hypothesis that the Golgi complex may be a potential membrane source for the biogenesis and development of autophagic structures.

• 出版日期2012-8