DYNAMICAL BEHAVIOR OF A NEW ONCOLYTIC VIROTHERAPY MODEL BASED ON GENE VARIATION

作者：Wang, Zizi; Guo, Zhiming^*; Peng, Huaqin

来源：Discrete and Continuous Dynamical Systems - Series S, 2017, 10(5): 1079-1093.

DOI：10.3934/dcdss.2017058

• Oncolytic virotherapy
• tumor growth modeling
• gene mutation
• reaction-diffusion equations with delay
• global stability

Oncolytic virotherapy is an experimental treatment of cancer patients. This method is based on the administration of replication-competent viruses that selectively destroy tumor cells but remain healthy tissue unaffected. In order to obtain optimal dosage for complete tumor eradication, we derive and analyze a new oncolytic virotherapy model with a fixed time period tau and non-local infection which is caused by the diffusion of the target cells in a continuous bounded domain, where tau is assumed to be the duration that oncolytic viruses spend to destroy the target cells and to release new viruses since they enter into the target cells. This model is a delayed reaction diffusion system with nonlocal reaction term. By analyzing the global stability of tumor cell eradication equilibrium, we give different treatment strategies for cancer therapy according to the different genes mutations (oncogene and antioncogene).

• 出版日期2017-10
• 单位广州大学