Use of diuretics is associated with reduced risk of Alzheimer%26apos;s disease: the Cache County Study

作者：Chuang Yi Fang; Breitner John C S; Chiu Yen Ling; Khachaturian Ara; Hayden Kathleen; Corcoran Chris; Tschanz JoAnn; Norton Maria; Munger Ron; Welsh Bohmer Kathleen; Zandi Peter P^*

来源：Neurobiology of Aging, 2014, 35(11): 2429-2435.

DOI：10.1016/j.neurobiolaging.2014.05.002

• Antihypertensive medications
• Diuretics
• Alzheimer%26apos
• s disease

Although the use of antihypertensive medications has been associated with reduced risk of Alzheimer%26apos;s disease (AD), it remains unclear which class provides the most benefit. The Cache County Study of Memory Health and Aging is a prospective longitudinal cohort study of dementing illnesses among the elderly population of Cache County, Utah. Using waves I to IV data of the Cache County Study, 3417 participants had a mean of 7.1 years of follow-up. Time-varying use of antihypertensive medications including different class of diuretics, angiotensin converting enzyme inhibitors, beta-blockers, and calcium channel blockers was used to predict the incidence of AD using Cox proportional hazards analyses. During follow-up, 325 AD cases were ascertained with a total of 23,590 person-years. Use of any antihypertensive medication was associated with lower incidence of AD (adjusted hazard ratio [aHR], 0.77; 95% confidence interval [CI], 0.61-0.97). Among different classes of antihypertensive medications, thiazide (aHR, 0.7; 95% CI, 0.53-0.93), and potassium-sparing diuretics (aHR, 0.69; 95% CI, 0.48-0.99) were associated with the greatest reduction of AD risk. Thiazide and potassium-sparing diuretics were associated with decreased risk of AD. The inverse association of potassium-sparing diuretics confirms an earlier finding in this cohort, now with longer follow-up, and merits further investigation.

• 出版日期2014-11
• 单位McGill