AKAPs: The architectural underpinnings of local cAMP signaling

作者：Kritzer Michael D; Li Jinliang; Dodge Kafka Kimberly; Kapiloff Michael S^*

来源：Journal of Molecular and Cellular Cardiology, 2012, 52(2): 351-358.

DOI：10.1016/j.yjmcc.2011.05.002

• PKA
• AKAP
• cAMP
• Compartmentation
• Scaffold
• Signaling

The cAMP-dependent protein kinase A (PKA) is targeted to specific compartments in the cardiac myocyte by A-kinase anchoring proteins (AKAPs), a diverse set of scaffold proteins that have been implicated in the regulation of excitation-contraction coupling and cardiac remodeling. AKAPs bind not only PKA, but also a large variety of structural and signaling molecules. In this review, we discuss the basic concepts underlying compartmentation of cAMP and PKA signaling, as well as a few of the individual AKAPs that have been shown to be functionally relevant in the heart. This article is part of a Special Issue entitled %26quot;Local Signaling in Myocytes%26quot;.

• 出版日期2012-2