An Approach to the Carbon Backbone of Bielschowskysin, Part 2: Non-Photochemical Strategy

作者：Farcet Jean Baptiste; Himmelbauer Martin; Mulzer Johann^*

来源：European Journal of Organic Chemistry, 2013, 2013(36): 8245-8252.

DOI：10.1002/ejoc.201300870

• Total synthesis
• Natural products
• Terpenoids
• Chromium
• Hydroalumination

The stereocontrolled synthesis of complex and highly substituted polycyclic synthetic precursor 2 of the diterpene bielschowskysin is presented. Key steps include a regio- and stereoselective hydroalumination as well as an optimized Cr/Ni-mediated carbon-carbon bond formation between two complex fragments to establish the northern hemisphere of the natural product.

• 出版日期2013-12