Are estrogen receptor-positive breast cancers in BRCA1 mutation carriers sporadic?

作者：Lakhani Sunil R^*; Khanna Kum Kum; Chenevix Trench Georgia

来源：Breast Cancer Research, 2010, 12(2): 104.

DOI：10.1186/bcr2483

There is a strong association between BRCA1 mutation carrier status and estrogen receptor-negative breast cancer. This has led to the idea that estrogen receptor-positive breast cancers in BRCA1 mutation carriers may be incidental or sporadic in nature and not as a direct result of BRCA1 dysfunction. A recent paper in Breast Cancer Research challenges this view.

• 单位
  河北医科大学