Limited allelic diversity of stimulatory two-domain killer cell immunoglobulin-like receptors

作者：Hou Lihua; Steiner Noriko K; Chen Minghua; Belle Ian; Kubit Anna L; Ng Jennifer; Hurley Carolyn Katovich^*

来源：Human Immunology, 2008, 69(3): 174-178.

DOI：10.1016/j.humimm.2008.01.009

• natural killer cell
• immune receptor
• immunogenetics
• killer cell immunoglobulin-like receptor

Genomic sequencing was used to characterize most of the coding regions of the five two-domain stimulatory killer cell immunoglobulin-like receptor (KIR) loci from 80 unrelated, primarily Caucasian, individuals. Specific Loci were present in from 26% (KIR2DS3) to 98% (KIR2DS4) of individuals. The number of known alleles present varied from one (KIR2DS1, KIR2DS5) to five (KIR2DS4). The frequencies of Loci and alleles were similar to observations made in populations of European and Asian ethnicities. New alleles were found at 2DS1 (*00202, '00302, *005, *006, *007) and 2DS4 (*008) loci.

• 出版日期2008-3