Quinoline-3-carboxamide Derivatives as Potential Cholesteryl Ester Transfer Protein Inhibitors

作者：Li, Wen-Yan; Xiong, Xu-Qiong; Zhao, Dong-Mei^*; Shi, Yu-Fang; Yang, Zhi-Heng; Yu, Chao; Fan, Pei-Wei; Cheng, Mao-Sheng; Shen, Jing-Kang

来源：Molecules, 2012, 17(5): 5497-5507.

DOI：10.3390/molecules17055497

• CETP inhibitors
• CETP
• quinoline-3-carboxamide derivatives
• synthesis
• high density lipoprotein cholesterol

A series of novel quinoline-3-carboxamide derivatives 10-17 and 23-27 were designed and synthesized as cholesteryl ester transfer protein (CETP) inhibitors. All of them exhibited activity against CETP. Particularly, compounds 24 and 26 displayed the best activity against CETP with the same inhibitory rate of 80.1%.

• 出版日期2012-5
• 单位沈阳药科大学