A new pyrrolidine-derived atropisomeric amino alcohol as a highly efficient chiral ligand for the asymmetric addition of diethylzinc to aldehydes

作者：Faigl Ferenc; Erdelyi Zsuzsa; Deak Szilvia; Nyerges Miklos; Matravoelgyi Bela

来源：Tetrahedron Letters, 2014, 55(50): 6891-6894.

DOI：10.1016/j.tetlet.2014.10.101

• Chiral ligand
• Amino alcohol
• Enantioselective addition
• Axial chirality
• Asymmetric catalysis

A highly efficient pyrrolidine-derived atropisomeric amino alcohol, (S-a)-1[2-diphenylhydroxymethyl-6-(trifluoromethyl)phenyl]-2-(1-pyrrolido)methyl-1H-pyrrole, has been synthesized as a chiral ligand for the enantioselective addition of diethylzinc to some prochiral aldehydes to afford (S)-alcohols. The conversion rates were close to quantitative with good to excellent enantiomeric excesses (up to 95% ee).

• 出版日期2014-12-10
• 单位河北医科大学