Mitotic crisis The unmasking of a novel role for RPA

作者：Anantha Rachel William; Borowiec James A^*

来源：Cell Cycle, 2009, 8(3): 357-361.

DOI：10.4161/cc.8.3.7496

• RPA
• Plk1
• centrosome
• mitotic DNA damage
• spindle assembly checkpoint
• phosphorylation

Mitotic DNA damage is a constant threat to genomic integrity, yet understanding of the cellular responses to this stress remain incomplete. Recent work by Anantha et al. (2008; PNAS 105: 12903-8) has found surprising evidence that RPA, the primary eukaryotic single-stranded DNA-binding protein, can stimulate the ability of cells to exit mitosis into a 2N G(1) phase. Along with providing additional discussion of this study, we review evidence suggesting that DNA replication and repair factors can modulate mitotic transit by acting through Polo-like kinase-1 (Plk1) and the centrosome.
'A crisis unmasks everyone.'-Mason Cooley, U. S. aphorist.

• 出版日期2009-2-1