A new chemical access for 3 '-acetyl-4 ' hydroxychalcones using borontrifluoride-etherate via a regioselective Cilaisen-Schmidt condensation and its application in the synthesis of chalcone hybrids

作者：Narender T^*; Venkateswarlu K; Nayak B Vishnu; Sarkar S

来源：Tetrahedron Letters, 2011, 52(44): 5794-5798.

DOI：10.1016/j.tetlet.2011.08.120

• Borontrifluoride-etherate
• Chalcone hybrids
• Regioselective Claisen-Schmidt condensation

A new chemical access has been developed for the synthesis of 3'-acetyl-4'-hydroxychalcones from 1-(5-acetyl-2-hydroxy-phenyl)-ethanone and various substituted benzaldehydes via a regioselective Claisen-Schmidt condensation using borontrifluoride-etherate (BF3 center dot OEt2) at room temperature, in good to excellent yields within 12-24 h. Application of this methodology has also been demonstrated in the synthesis of chalcone hybrids.

• 出版日期2011-11-2