Association of the g.19074G > A genetic variant in the osteoprotegerin gene with bone mineral density in Chinese postmenopausal women

作者：Zhang, Y. D.^*; Zhang, Z.; Zhou, N. F.; Jia, W. T.; Cheng, X. G.; Wei, X. J.

来源：Genetics and Molecular Research, 2014, 13(3): 6646-6652.

DOI：10.4238/2014.August.28.9

• Bone mineral density
• Genetic variant
• Osteoprotegerin gene
• Primary osteoporosis
• Risk factor

Primary osteoporosis is a common health problem in postmenopausal women. This study aimed to detect the association of the g.19074G>A genetic variant in the osteoprotegerin gene (OPG) with bone mineral density (BMD) and primary osteoporosis. The created restriction site-polymerase chain reaction method was used to investigate the g.19074G>A genetic variant. The BMD of the femoral neck hip, lumbar spine (L2-4), and total hip were assessed by dual-energy X-ray absorptiometry (DEXA) in 856 unrelated Chinese postmenopausal women. We found significant differences in the BMDs of the femoral neck hip, lumbar spine (L2-4), and total hip among different genotypes; individuals with the GG genotype had significantly higher BMDs than those with the GA and AA genotypes (P < 0.05). Our results indicated that the A allele was an increased risk factor for primary osteoporosis and the g.19074G>A genetic variant of the OPG gene was associated with BMD and primary osteoporosis in Chinese postmenopausal women.

• 出版日期2014
• 单位同济大学; 上海交通大学; 北京大学