Hydrogenolysis of the C-O bond of hydroxylactams as a convenient method for the synthesis of substituted isoindolin-1-ones

作者：Sagirova Zh R; Starodubtseva E V; Turova O V; Vinogradov M G^*

来源：Russian Chemical Bulletin, 2013, 62(4): 1032-1037.

DOI：10.1007/s11172-013-0137-7

• hydroxylactams
• mono- and disubstituted isoindolin-1-ones
• C-O-hydrogenolysis
• palladium catalyst

A simple and efficient method for the synthesis of isoindolin-1-ones containing alkyl or aryl substituents at positions 2 and (or) 3 was suggested. The method is based on the earlier unknown Pd-0-catalyzed hydrogenolysis of hydroxylactams.

• 出版日期2013-4