The axonal damage marker tau protein in the cerebrospinal fluid is increased in patients with acute encephalopathy with biphasic seizures and late reduced diffusion

作者：Tanuma Naoyuki^*; Miyata Rie; Kumada Satoko; Kubota Masaya; Takanashi Jun ichi; Okumura Akihisa; Hamano Shin ichiro; Hayashi Masaharu

来源：Brain & Development, 2010, 32(6): 435-439.

DOI：10.1016/j.braindev.2009.07.004

• Acute encephalopathy
• Tau protein
• Axonal damage

Acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) is a recently clinicoradiologically-established encephalopathy syndrome. In the present study, we examined the levels of cerebrospinal fluid (CSF) tau protein, a marker of axonal damage, in 11 patients with AESD. CSF tau levels were normal on day I and increased from day 3 of the disease between the initial and the secondary seizures. Magnetic resonance imaging (MRI) reveals reduced diffusion in the subcortical white matter during days 3-7. Two patients showed elevated tau protein prior to the diffusion abnormality of subcortical white matter on MRI. Levels of CSF neuron specific enolase (NSE), a neuronal marker, were elevated in only two out of seven patients with AESD, and CSF tau levels were also increased in these patients. Our results indicated that tau protein is a more sensitive marker than NSE and axonal damage causes the conspicuous M RI findings in AESD patients. A therapeutic strategy for axonal protection should be developed to prevent severe neurological impairment of A ESD patients.

• 出版日期2010-6