Muscle PGC-1 alpha modulates satellite cell number and proliferation by remodeling the stem cell niche

作者：Dinulovic Ivana; Furrer Regula; Beer Markus; Ferry Arnaud; Cardel Bettina; Handschin Christoph^*

来源：Skeletal Muscle, 2016, 6(1): 39.

DOI：10.1186/s13395-016-0111-9

• PGC-1 alpha
• Satellite cells
• Satellite cell niche
• Basal lamina
• Fibronectin
• Skeletal muscle

Background: The myogenic capacity of satellite cells (SCs), adult muscle stem cells, is influenced by aging, exercise, and other factors. In skeletal muscle, the peroxisome proliferator-activated receptor. coactivator 1a (PGC-1 alpha) is a key regulator of oxidative metabolism and endurance training adaptation. However, a link between PGC-1 alpha and SC behavior remains unexplored.
Methods: We have now studied SC function in a PGC-1 alpha fiber-specific gain-of-function animal model.
Results: In surprising contrast to bona fide exercise, muscle-specific PGC-1 alpha transgenic mice have lower SC numbers. Nevertheless, SCs from these mice have a higher propensity for activation and proliferation. Intriguingly, muscle PGC-1 alpha triggers a remodeling of the SC niche by altering the extracellular matrix composition, including the levels of fibronectin, which affects the proliferative output of SCs.
Conclusions: Taken together, PGC-1 alpha indirectly affects SC plasticity in skeletal muscle and thereby might contribute to improved SC activation in exercise.

• 出版日期2016-12-2