Dose-response effects of marine omega-3 fatty acids on apolipoproteins, apolipoprotein-defined lipoprotein subclasses, and Lp-PLA(2) in individuals with moderate hypertriglyceridemia

作者：Skulas Ray Ann C^*; Alaupovic Petar; Kris Etherton Penny M; West Sheila G

来源：Journal of Clinical Lipidology, 2015, 9(3): 360-367.

DOI：10.1016/j.jacl.2014.12.001

• Apolipoproteins
• Lipoproteins
• Lp-PLA(2)
• Omega-3
• Docosahexaenoic acid
• Eicosapentaenoic acid
• Triglycerides
• Fish oil

BACKGROUND: Apolipoprotein (apo) distribution and lipoprotein (Lp)-associated markers of inflammation, such as lipoprotein-associated phospholipase A(2) (Lp-PLA(2)), influence the atherogenicity of circulating lipids and lipoproteins. Little evidence exists regarding the dose-response effects of the marine omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on apos, apo-defined Lps, and Lp-PLA(2).
OBJECTIVE: The purpose of this study was to compare the effects of 0, 0.85, and 3.4 g/d of EPA + DHA on Lp-PLA(2) mass and activity in individuals with moderate hypertriglyceridemia. We also measured effects on concentrations of apoAI, apoAII, apoB, apoC, apoD, and apoE-defined Lp subclasses.
METHODS: The study was a randomized, doubleblind, crossover design with 8-week treatment periods and 6-week washout periods. During the 3 treatment periods, subjects (n = 25) received 0 g/d EPA + DHA, 0.85 g/d EPA + DHA (low dose), and 3.4 g/d EPA + DHA (high dose) in random order.
RESULTS: apoB and apoC-Ill were significantly decreased by the high dose relative to placebo and low dose (P < .01), as was very low density lipoprotein cholesterol (P < .005). The low dose had no effect on Lp outcomes compared with placebo. The high- and low-dose effects differed significantly for heparin-precipitated apoC-III, LpB, LpA-I, and apoB/apoA-I ratio (P < .05). There was a trend for a decreased Lp-PLA(2) mass with the high dose (P = .1).
CONCLUSION: The effects of 3.4 g/d EPA + DHA on apoB and apoC-III may reduce atherosclerotic plaque progression in individuals with elevated triglycerides.

• 出版日期2015-6