Oppositinines A and B: New Vasorelaxant beta-Carboline Alkaloids from Neisosperma oppositifolia

作者:Ahmad Kartini; Thomas Noel F; Hadi A Hamid A; Mukhtar Mat Ropi; Mohamad Khalit; Nafiah Mohd Azlan; Takeya Koichi; Morita Hiroshi; Litaudon Marc; Arai Hiroko; Awang Khalijah*
来源:Chemical & Pharmaceutical Bulletin, 2010, 58(8): 1085-1087.
DOI:10.1248/cpb.58.1085

摘要

A phytochemical study on the bark of Neisosperma oppositifolia (Apocynaceae) yielded two new beta-carboline indole alkaloids, oppositinines A (1) and B (2), together with five known alkaloids, isoreserpiline, isocarapanaubine, vobasine, 10-methoxydihydrocorynantheol-N-oxide, and ochropposinine oxindole. Structural elucidation of 1 and 2 was performed using 21) NMR methods. Oppositinines A (1) and B (2) showed potent vasorelaxant effects on the rat aorta.

  • 出版日期2010-8