Alstilobanines A-E, new indole alkaloids from Alstonia angustiloba

作者：Koyama Koichiro; Hirasawa Yusuke; Zaima Kazumasa; Hoe Teh Chin; Chan Kit Lam; Morita Hiroshi^*

来源：Bioorganic & Medicinal Chemistry, 2008, 16(13): 6483-6488.

DOI：10.1016/j.bmc.2008.05.033

• alkaloids
• Alstonia angustiloba
• alstilobanines A-E
• vasorelaxant activity

Five new alkaloids, alstilobanines A (1)-E (5) were isolated from Alstonia angustiloba (Apocynaceae) and their structures were determined by MS and 2D NMR spectral analysis. Alstilobanines A-E showed a moderate vasorelaxant activity against phenylephrine-induced contraction of isolated rat aorta.

• 出版日期2008-7-1