An understanding of renal stone development in a mixed oxalate-phosphate system

作者：Guan Xiangying; Wang Lijun; Dosen Anja; Tang Ruikang; Giese Rossman F; Giocondi Jennifer L; Orme Christine A; Hoyer John R; Nancollas George H^*

来源：Langmuir, 2008, 24(14): 7058-7060.

DOI：10.1021/la8007987

The in vivo formation of calcium oxalate concretions having calcium phosphate nidi is simulated in an in vitro (37 degrees C, pH 6.0) dual constant composition (DCC) system undersaturated (sigma(DCPD) = -0.330) with respect to brushite (DCPD, CaHPO(4)center dot 2H(2)O) and slightly supersaturated (sigma(COM) = 0.328) with respect to calcium oxalate monohydrate (COM, CaC(2)O(4)center dot H(2)O). The brushite dissolution provides calcium ions that raise the COM supersaturation, which is heterogeneously nucleated either on or near the surface of the dissolving calcium phosphate crystals. The COM crystallites may then aggregate, simulating kidney stone formation. Interestingly, two intermediate phases, anhydrous dicalcium phosphate (monetite, CaHPO(4)) and calcium oxalate trihydrate (COT), are also detected by X-ray diffraction during this brushite-COM transformation. In support of clinical observations, the results of these studies demonstrate the participation of calcium phosphate phases in COM crystallization providing a possible physical chemical mechanism for kidney stone formation.

• 出版日期2008-7-15
• 单位浙江大学