科研之友
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摘要
Purpose: To develop a new spectrophotometric method for the analysis of losartan potassium in pharmaceutical formulations by making its complex with copper. Method: A coloured complex based on UV/Vis spectroscopic method was developed for the determination of losartan potassium concentration in pharmaceutical formulations in the visible region. The colored complex of losartan was formed with cupric acetate (5: 4). Analysis was carried out by the two methods - absorption ratio and calibration curve methods. The proposed method was validated in terms of linearity, accuracy and precision. Results: The lambda maximum of the complex was recorded at 530 nm. Beer's law was obeyed in the range of 10 - 50 mu g/ml with a correlation coefficient (r(2)) of 0.9989. Mean analytical results from the calibration curve and absorption ratio methods were 99.42 and 99.16 % with relative standard deviation (RSD) of 0.97 and 0.82 %, respectively. Mean recovery was between 98.61 and 101.35 % and precision expressed as relative standard deviation (RSD) was 0.91 %. Conclusion: The proposed method is simple, easy to apply, low-cost, and requires relatively inexpensive instruments. Thus, it is a suitable alternative to currently used spectrophotometric methods for the determination of losartan in bulk and solid dosage forms.
- 出版日期2013-6
