Nuclear assembly as a target for anti-cancer therapies

作者：Gorjanacz Matyas^*

来源：Nucleus, 2014, 5(1): 47-55.

DOI：10.4161/nucl.27928

• nucleus
• nuclear organization
• nuclear envelope
• barrier-to-autointegration factor
• vaccinia-related kinase
• cell cycle
• cancer
• anti-mitotics
• drug discovery

Current anti-cancer therapies have a great deal of undesirable side effects; therefore, there is a need to develop efficient and cancer cell-specific new drugs without strong dose-limiting side effects. In my opinion, mechanisms of nuclear assembly and organization represent a novel platform for drug targets, which might fulfill these criteria. The nuclear stiffness and organization of some cancer types are often compromised, making them more vulnerable for further targeting the mechanisms of nuclear integrity than their normal counterparts. Here I will discuss the nuclear organization of normal cells and cancer cells, the molecular mechanisms that govern nuclear assembly with emphasis on those that, in my view, might be considered as targets for future anti-cancer therapies.

• 出版日期2014-2