Ductal Closure With Paracetamol: A Surprising New Approach to Patent Ductus Arteriosus Treatment

作者：Hammerman Cathy^*; Bin Nun Alona; Markovitch Einat; Schimmel Michael S; Kaplan Michael; Fink Daniel

来源：Pediatrics, 2011, 128(6): E1618-E1621.

DOI：10.1542/peds.2011-0359

• patent ductus arteriosus
• paracetamol
• ibuprofen

Standard pharmacologic closure of the patent ductus arteriosus currently involves the administration of 1 of 2 cyclooxygenase inhibitors: either indomethacin or ibuprofen. However, both of these drugs can be associated with potentially significant adverse effects. We present here the cases of 5 preterm infants (gestational age: 26-32 weeks; postnatal age: 3-35 days) with large, hemodynamically significant patent ductus arteriosus who had either failed or had contraindications to ibuprofen therapy. Each of these infants was treated with off-label oral paracetamol (15 mg/kg per dose every 6 hours). Ductal closure was achieved within 48 hours in all the treated infants. No toxicity was observed. Pediatrics 2011; 128:e1618-e1621

• 出版日期2011-12