Diastereoselective synthesis of peptidomimetics in one-pot Ugi reaction using trans-4-isopropylcyclohexanecarboxylic acid

作者：Ramezanpour Sorour^*; Panahi Akram; Rominger Frank

来源：Monatshefte fur Chemie, 2018, 149(3): 625-633.

DOI：10.1007/s00706-017-2086-6

• Multicomponent condensation
• Trans-4-isopropylcyclohexanecarboxylic acid
• Amino acid-derived

The use of trans-4-isopropylcyclohexanecarboxylic acid as a substitution for the carboxylic acid component in the Ugi multicomponent condensation that leads to (1R,4R)-N-(2-(cyclohexylamino)-2-oxo-4-isopropylcyclohexane-1-carboxamide derivatives is described for the first time. One pot, clean reaction, and excellent yields are some advantages of this protocol.
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• 出版日期2018-3