Analysis of llicit and illicit drugs in waste, surface and lake water samples using large volume direct injection high performance liquid chromatography - Electrospray tandem mass spectrometry (HPLC-MS/MS)

作者：Berset Jean Daniel^*; Brenneisen Rudolf; Mathieu Christoph

来源：Chemosphere, 2010, 81(7): 859-866.

DOI：10.1016/j.chemosphere.2010.08.011

• Llicit/illicit drugs
• Metabolites
• Cocaine
• Wastewater
• Surface water
• HPLC-MS/MS

Llicit and illicit drugs represent a recent group of emerging contaminants and have been found in the aquatic environment A HPLC-MS/MS method was developed using direct injection (DI) of larger volumes and a polar endcapped reversed-phase (RP) column to measure drug components in water samples belonging to the cocaine group opiates amphetamine-like stimulants and metabolites thereof After validation including sensitivity linearity recovery precision and matrix effect studies most drugs could be detected with limits of quantitation (LOQ) of 20 ng L(-1) in wastewater (WW) and 0 2 ng L(-1) in surface water The major substances found in influents and effluents were cocaine (COC) benzoylecgonine (BE) morphine (MO) methadone (MD) and its main metabolite 2 ethylidene-1 5-dimethyl 3 3-diphenyl-pyrrolidine (EDDP) with concentrations up to 2 mu g L(-1) followed by codeine (COD) and the amphetamines which ranged between 20 and 400 ng L(-1) Except for MO COD and EDDP levels were generally lower in the effluents River and lake water contained trace amounts of mainly BE MD and EDDP from the high pg L(-1) to the low ng L(-1) level Monitoring COC and BE levels over 11 consecutive days in influents and effluents suggests a consumption preference on week-end days Finally measuring an influent after a major music event revealed that sewage treatment

• 出版日期2010-11