Modulation of platelet-derived microparticles to adhesion and motility of human rheumatoid arthritis fibroblast-like synoviocytes

作者：Wang, Wenwen; Liu, Jiahuan; Yang, Binzhou; Ma, Zhongshuang; Liu, Guiping; Shen, Weigan^*; Zhang, Yu^*

来源：PLos One, 2017, 12(7): 0181003.

DOI：10.1371/journal.pone.0181003

• NF-KAPPA-B
• SYNOVIAL FIBROBLASTS
• DISEASE-ACTIVITY
• ACTIVATION
• PATHOGENESIS
• INFLAMMATION
• MMP-1
• CELL

Platelet-derived microparticles (PMPs) are closely associated with disease activity in rheumatoid arthritis (RA) and contribute to the inflammatory process. Rheumatoid arthritis fibroblast-like synoviocytes (RA-FLSs) play important roles in the progression of joint destruction. The aim of this study is to demonstrate whether PMPs affect the adhesion and motility of RA-FLSs. Our data indicated that PMPs promoted migration, invasion and adhesion to extracellular matrix (ECM) of RA-FLSs. Further study showed that PMPs up-regulated the expression of matrix metalloproteinase-1 (MMP1) and increased the level of phosphorylation of NF-kappa B (p-NF-kappa B) and Erk (p-Erk) in RA-FLSs. These results suggest that PMPs promote RA-FLSs adhesion and motility presumably by increasing MMP1 via activating Erk-mediated NF-kappa B pathway.

• 出版日期2017-7-13
• 单位扬州大学; 西南交通大学