Differentially Degradable Janus Particles for Controlled Release Applications

作者：Hwang Sangyeul; Lahann Joerg^*

来源：Macromolecular Rapid Communications, 2012, 33(14): 1178-1183.

DOI：10.1002/marc.201200054

• colloids
• crosslinking
• degrdation
• drug delivery systems
• esterification

Janus particles with differentially degradable compartments were prepared by electrohydrodynamic (EHD) co-jetting and subsequent controlled crosslinking. These bicompartmental particles are composed of an interpenetrating polymer network of poly(ethylene oxide) and poly(acrylamide-co-acrylic acid) in one hemisphere and a crosslinked copolymer of dextran and poly(acrylamide-co-acrylic acid) segments in the second compartment. The compositional anisotropy caused differential hydrolytic susceptibility: Although both compartments were stable at pH 3.0, selective degradation of the PEO-containing compartment pH 7.4 was observed wtihin 5 days. Janus particles with differentially degradable polymer compartments may be of interest for a range of oral drug delivery applications because of their propensity for decoupled release profiles.

• 出版日期2012-7-26