Adipocytes role in the bone marrow niche

作者：Guerra Daniel A. P.; Paiva Ana E.; Sena Isadora F. G.; Azevedo Patrick O.; Batista Miguel Luiz Jr.; Mintz Akiva; Birbrair Alexander^*

来源：Cytometry, Part A, 2018, 93A(2): 167-171.

DOI：10.1002/cyto.a.23301

• adipocytes
• hematopoiesis
• hematopoietic stem cells
• bone marrow

Adipocyte infiltration in the bone marrow follows chemotherapy or irradiation. Previous studies indicate that bone marrow fat cells inhibit hematopoietic stem cell function. Recently, Zhou et al. (2017) using state-of-the-art techniques, including sophisticated Cre/loxP technologies, confocal microscopy, in vivo lineage-tracing, flow cytometry, and bone marrow transplantation, reveal that adipocytes promote hematopoietic recovery after irradiation. This study challenges the current view of adipocytes as negative regulators of the hematopoietic stem cells niche, and reopens the discussion about adipocytes' roles in the bone marrow. Strikingly, genetic deletion of stem cell factor specifically from adipocytes leads to deficiency in hematopoietic stem cells, and reduces animal survival after myeloablation, The emerging knowledge from this research will be important for the treatment of multiple hematologic disorders.

• 出版日期2018-2