Adipocyte-specific disruption of mouse Cnot3 causes lipodystrophy

作者：Li Xue; Morita Masahiro; Kikuguchi Chisato; Takahashi Akinori; Suzuki Toru^*; Yamamoto Tadashi^*

来源：FEBS LETTERS, 2017, 591(2): 358-368.

DOI：10.1002/1873-3468.12550

• Cnot3
• cold intolerance
• lipodystrophy

Lipodystrophy involves a loss of adipose tissue. In mice, disruption of adipose tissue Cnot3, a subunit of the CCR4-NOT deadenylase complex, causes adipose tissue anomalies. In Cnot3(ad-/-) mice, white adipose tissue (WAT) decreases concomitantly with enhanced inflammation, whereas brown adipose tissue increases and contains larger lipid droplets. Cnot3(ad-/-) mice show hyperinsulinemia, hyperglycemia, insulin resistance, and glucose intolerance, and cannot maintain body temperature during cold exposure. Increased expression of inflammatory genes and decreased leptin expression also occur in Cnot3(ad-/-) WAT, achieving levels similar to those in lipodystrophic aP2-nSrebp1c and Pparg(ldi/+) mice; thus, Cnot3(ad-/-) mice exhibit lipodystrophy.

• 出版日期2017-1
• 单位McGill; RIKEN