Design, synthesis and in vitro cytotoxicity of novel dinuclear platinum(II) complexes

作者：Gao Chuanzhu; Gou Shaohua^*; Fang Lei; Zhao Jian

来源：Bioorganic & Medicinal Chemistry Letters, 2011, 21(6): 1763-1766.

DOI：10.1016/j.bmcl.2011.01.064

• 1R,2R-Diaminocyclohexane derivative
• Dinuclear platinum(II) complexes
• Antitumor activity

Five dinuclear platinum(II) complexes with a novel chiral ligand, 2-(((1R,2R)-2-aminocyclohexylamino)methyl)phenol (HL), were designed, prepared and spectrally characterized. In vitro cytotoxicity of all the resulting platinum(II) compounds was evaluated against human HEPG-2, A549 and HCT-116 cell lines, respectively. Results indicated that all compounds showed positive biological activity. Particularly, compound D4 has lower IC(50) values than carboplatin toward HEPG-2 and A549, while compound D5 shows better activity than carboplatin against A549.

• 出版日期2011-3-15
• 单位东南大学