An optimized extraction technique for acetylcholinesterase inhibitors from the Camellia japonica seed cake by using response surface methodology

作者：Kim Jae Kyeom; Kim Cho Rong; Lim Ho Jeong; Nam Sang Hae; Joo Ok Soo; Shin Dong Hoon; Shin Eui Cheol^*

来源：Bioscience Biotechnology and Biochemistry, 2014, 78(7): 1237-1241.

DOI：10.1080/09168451.2014.915723

• Camellia japonica
• camellia seed cake
• acetylcholinesterase
• Alzheimer's disease
• response surface methodology

The response surface methodology (RSM) was used to optimize the extraction conditions for the acetylcholinesterase (AchE) inhibitory activity and extraction yield from Camellia japonica seed cake. Predicted values for AchE inhibition and extraction yield were 19.41 and 13.35%, respectively, which are in good agreement with the experimental values from validation, suggesting that RSM may provide a useful tool to optimization processes.

• 出版日期2014-7