Associations of night-time road traffic noise with carotid intima-media thickness and blood pressure: The Whitehall II and SABRE study cohorts

作者：Halonen Jaana I; Dehbi Hakim Moulay^*; Hansell Anna L; Gulliver John; Fecht Daniela; Blangiardo Marta; Kelly Frank J; Chaturvedi Nish; Kivimaki Mika; Tonne Cathryn

来源：Environment International, 2017, 98: 54-61.

DOI：10.1016/j.envint.2016.09.023

• Cardiovascular
• Cohort study
• Epidemiology
• Hypertension
• Traffic noise

Background: Road traffic noise has been linked to increased risk of stroke, for which hypertension and carotid intima-media thickness (cIMT) are risk factors. A link between traffic noise and hypertension has been established, but there are few studies on blood pressure and no studies on cIMT.
Objectives: To examine cross-sectional associations for long-term exposure to night-time noise with cIMT, systolic blood pressure (SBP), diastolic blood pressure (DBP) and hypertension.
Methods: The study population consisted of 2592 adults from the Whitehall II and SABRE cohort studies living within Greater London who had cIMT, SBP and DBP measured. Exposure to night-time road traffic noise (A-weighted dB, referred to as dBA) was estimated at each participant's residential postcode centroid.
Results: Mean night-time road noise levels were 52 dBA (SD=4). In the pooled analysis adjusted for cohort, sex, age, ethnicity, marital status, smoking, area-level deprivation and NOx there was a 9.1 mu m (95% CI: -7.1, 25.2) increase in cIMT in association with 10 dBA increase in night-time noise. Analyses by noise categories of 5560 dBA (16.2 mu m, 95% CI:-8.7, 41.2), and N60 dBA (21.2 mu m, 95% CI:-2.5, 44.9) vs. <55 dBA were also positive but non-significant, expect among those not using antihypertensive medication and exposed to >60 dBA vs. <55 dBA (32.6 mu m, 95% CI: 6.2, 59.0). Associations for SBP, DPB and hypertension were close to null.
Conclusions: After adjustments, including for air pollution, the association between night-time road traffic noise and cIMT was only observed among non-medication users but associations with blood pressure and hypertension were largely null.

• 出版日期2017-1