Alcohol-induced neuroapoptosis in the fetal macaque brain

作者：Farber Nuri B^*; Creeley Catherine E; Olney John W

来源：Neurobiology of Disease, 2010, 40(1): 200-206.

DOI：10.1016/j.nbd.2010.05.025

• Ethanol
• Alcohol
• Macaque
• Apoptosis
• Caspase-3
• Fetal alcohol syndrome
• Fetal alcohol spectrum disorder
• Non-human primate
• Schizophrenia
• Bipolar disorder

The ability of brief exposure to alcohol to cause widespread neuroapoptosis in the developing rodent brain and subsequent long-term neurocognitive deficits has been proposed as a mechanism underlying the neurobehavioral deficits seen in fetal alcohol spectrum disorder (FASD). It is unknown whether brief exposure to alcohol causes apoptosis in the fetal primate brain. Pregnant fascicularis macaques at various stages of gestation (G105 to G155) were exposed to alcohol for 8 h, then the fetuses were delivered by caesarian section and their brains perfused with fixative and evaluated for apoptosis. Compared to saline control brains, the ethanol-exposed brains displayed a pattern of neuroapoptosis that was widespread and similar to that caused by alcohol in infant rodent brain. The observed increase in apoptosis was on the order of 60-fold. We propose that the apoptogenic action of alcohol could explain many of the neuropathological changes and long-term neuropsychiatric disturbances associated with human FASD.

• 出版日期2010-10