Association of body mass index with arterial stiffness and blood pressure components: A twin study

作者：Tarnoki Adam Domonkos^*; Tarnoki David Laszlo; Bogl Leonie H; Medda Emanuela; Fagnani Corrado; Nistico Lorenza; Stazi Maria Antonietta; Brescianini Sonia; Lucatelli Pierleone; Boatta Emanuele; Zini Chiara; Fanelli Fabrizio; Baracchini Claudio; Meneghetti Giorgio; Osztovits Janos; Jermendy Gyorgy; Kiss Robert Gabor; Preda Istvan; Karlinger Kinga; Lannert Agnes; Molnar Andrea Agnes; Littvay Levente; Garami Zsolt; Berczi Viktor; Pucci Giacomo; Baffy Gyorgy

来源：Atherosclerosis, 2013, 229(2): 388-395.

DOI：10.1016/j.atherosclerosis.2013.05.001

• Central blood pressure
• Augmentation index
• Pulse wave velocity
• Hypertension
• Obesity
• Twin study

Rationale: Obesity, blood pressure and arterial stiffness are heritable traits interconnected to each other but their possible common genetic and environmental etiologies are unknown. %26lt;br%26gt;Methods: We studied 228 monozygotic and 150 dizygotic twin pairs aged 18-82 years from Italy, Hungary and the United States, of which 45 monozygotic and 38 dizygotic pairs were discordant for body mass index (BMI; intrapair difference (Delta) in BMI %26gt;= 3 kg/m(2)). Blood pressure components and arterial stiffness were measured by TensioMed Arteriograph. %26lt;br%26gt;Results: Hypertension was more prevalent among obese than non-obese individuals (55% vs. 29%, p %26lt; 0.001). Age-, sex-and country-adjusted heritability estimates were high for hemodynamic measures (45%-58%) and BMI (78%). According to bivariate Cholesky decomposition, phenotypic correlations between BMI and blood pressure components (r = -0.15 to 0.24, p %26lt; 0.05) were largely explained by additive genetic factors (65%-77%) with the remaining explained by the unique environment. When controlling for genetic factors within all monozygotic pairs, Delta BMI was significantly correlated with Delta brachial systolic blood pressure (SBP) and diastolic blood pressure (DBP), Delta mean arterial pressure, and Delta aortic SBP (r = 0.15-0.17, p %26lt; 0.05). For the same measures, heavier co-twins of BMI-discordant monozygotic pairs had significantly higher values than their leaner counterparts (p %26lt; 0.05). %26lt;br%26gt;Conclusion: Blood pressure components are moderately correlated with BMI, largely because of shared genetic factors. However, for the association of BMI with brachial SBP and DBP, aortic SBP and mean arterial pressure, acquired, modifiable factors were also found to be important.

• 出版日期2013-8