An Efficient Synthesis of Spiro[indoline-3,9 '-xanthene]trione Derivatives Catalyzed by Magnesium Perchlorate

作者：Chen, Chunfeng; Lv, Chunlei; Liang, Jianfeng; Jin, Jianqing; Wang, Lijun; Wu, Chunlei^*; Shen, Runpu^*

来源：Molecules, 2017, 22(8): 1295.

DOI：10.3390/molecules22081295

• aqueous
• isatin
• spiro[indoline-3,9 '-xanthene]trione
• magnesium perchlorate

A simple and efficient method for the synthesis of spiro[indoline-3,9'-xanthene]trione derivatives by means of condensation between isatins and 1,3-cyclohexanedione in the presence of a catalytic amount of magnesium perchlorate at 80 degrees C in 50% aqueous ethanol medium has been described. Notably, the present method offers desirable advantages of good yields, simplicity of workup procedure, easy purification, and reduced reaction times.

• 出版日期2017-8
• 单位绍兴文理学院