Association between IL-35 and coronary arterial lesions in children with Kawasaki disease

作者：Su, Ya; Feng, Siqi; Luo, Li; Liu, Ruixi^*; Yi, Qijian^*

来源：Clinical and Experimental Medicine, 2019, 19(1): 87-92.

DOI：10.1007/s10238-018-0513-6

• Kawasaki disease (KD)
• Interleukin-35 (IL-35)
• Interleukin-17A (IL-17A)
• Interleukin-10 (IL-10)
• Coronary arterial lesion

Kawasaki disease (KD) arises due to the acute inflammation and immune system dysfunction. This study investigated the relationship between the serum level of IL-35 and coronary artery lesions (CALs) in patients with KD. We obtained blood samples from 90 children with KD before intravenous immunoglobulin therapy. Levels of IL-35, IL-6, IL-17A, IL-10, MCP-1 and VEGF were measured in 190 cases, including 4 groups: KD with coronary arterial lesions (n=46), KD without coronary arteries lesions (n=44), febrile control group (FC, n=40) and the normal control group (NC, n=60). White blood cell counts (WBC), red blood cell counts (RBC), hemoglobin, platelet, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) and procalcitonin were tested in all subjects. Levels of IL-35, RBC and hemoglobin significantly decreased, and IL-6, IL-17A, IL-10, MCP-1 and VEGF were significantly elevated in the KD group compared with febrile and control groups. IL-35 serum level even decreased, and ESR, IL-6, MCP-1 and VEGF increased in the KD patients with CALs. Serum levels of IL-35 in KD patients were negatively associated with WBC, CRP, IL-6, IL-17A, IL-10, MCP-1 and VEGF in children with KD. IL-35 may have the effect on inhibiting inflammatory process in KD and further preventing KD patients from coronary artery lesion.

• 出版日期2019-2
• 单位重庆医科大学