Direct asymmetric Michael addition of phthalide derivatives to chalcones

作者：Luo, Jie; Jiang, Chunhui; Wang, Haifei; Xu, Li-Wen; Lu, Yixin^*

来源：Tetrahedron Letters, 2013, 54(38): 5261-5265.

DOI：10.1016/j.tetlet.2013.07.108

• Michael addition
• Phthalide derivatives
• Chalcones
• Organocatalysis
• Quinine thiourea catalyst

The Michael addition of phthalides to chalcones employing a quinidine-derived thiourea catalyst Q-1 has been developed. The reported method led to the synthesis of 3,3-disubstituted phthalide derivatives in excellent yields, with excellent diastereo- and enantioselectivities.

• 出版日期2013-9-18
• 单位湖南工业大学; 杭州师范大学