Antimycobacterial activity of lichens

作者：Gupta Vivek Kumar; Darokar Mahendra P; Saikia Dharmendra; Pal Anirban; Fatima Atiya; Khanuja Suman P S^*

来源：Pharmaceutical Biology, 2007, 45(3): 200-204.

DOI：10.1080/13880200701213088

• antimycobacterial agents
• BACTEC
• lichens
• Mycobacterium tuberculosis
• radiometric assay

Ethanol extracts of nine lichen species, namely Everniastrum cirrhatum ( Fr.) Hale ex Sipman ( Parmeliaceae), Flavoparmelia caperata ( L) Hale ( Parmeliaceae), Heterodermia leucomela ( L) Poelt ( Physciaceae), Lecanora flavidorufa Hue ( Lecanoraceae), Leptogium pedicellatum P. M. Jorg ( Collemataceae), Lobaria isidiosa ( Bory) Trevisan ( Stictaceae), Rimelia reticulata ( Taylor) Hale and Fletcher ( Parmeliaceae), Phaeophyscia hispidula ( Ach.) Essl ( Physciaceae), and Stereocaulon foliolosum Nyl. ( Stereocaulaceae), were evaluated for antimycobacteral properties against Mycobacterium tuberculosis H(37)Rv and H37Ra strains using the radiometric BACTEC method. Among the tested lichens, the virulent strain of M. tuberculosis H37Rv was found more susceptible to ethanol extract of F. caperata and H. leucomela( MIC 250 mu g/mL). E. cirrhatum, R. reticulata, and S. foliolosum were found active at the concentration of 500 mu g/mL. L. isidiosa, L. pedicellatum, P. hispidula, and L. flavidorufa did not exhibit activity at the maximum tested concentration of 1000 mu g/mL.

• 出版日期2007
• 单位河北医科大学